피질골 골결손부에서 Oxidized Cellulose 피개의 영향에 관한 실험적 연구
AN EXPERIMENTAL STUDY ON THE EFFECTS OF OXIDIZED CELLULOSE COVERAGE ON THE CORTICAL BONY DEFECTS
김회종, 임재석,
소속 상세정보
김회종 ( ) - 고려대학교 의과대학 외과학교실
임재석 ( ) - 고려대학교 의과대학 구강악안면외과학교실
KMID : 0360119980200020112
Abstract
결론
Oxidized cellulose의 유지기간 및 유지기간동안 연조직의 침투를 효과적으로 차단하는지
확인하고자, 치과구강외과 영역에서 빈번히 접하는 작은 낭종과 같은 조건이 되도록 성견
경골의 피질골내에 형성한 골결손부 상방에 oxidized cellulose막을 피개한 실험군과 피개하
지 않은 대조군을 1일, 2일, 3일, 4일, 5일, 6일, 7일, 10일, 14일, 21일, 28일 간격으로 육안
적, 광학현미경적 비교 관찰을 한 후 다음과 같은 결론을 얻었다.
1. Oxidized cellulose의 흡수에 의한 염증반응은 대조군과 비교해 큰 차이가 없었으며 위해
한 작용도 나타나지 않았다.
2. Oxidized cellulose는 술후 10일 이상까지 지속적으로 잔존하였으며, 술후 14일 정도에 완
전 흡수되었다.
3. 술후 14일, 21일, 28일째 실험군에서 신생골형성이 대조군에 비하여 양호하였으며 형성양
상은 비교적 정형화되었다.
4. 실험군에서 상부연조직이 골결손부 내로 유입된 흔적은 없었다
이상의 소견으로 oxidized cellulose는 성견의 경골 골막하에서 10일이상 유지되었으며 유
지되는 동안 연조직의 침투를 효과적으로 차단하였다.
따라서 흡수성인 oxidized cellulose막은 임상적 상황에 따라 흡수성 차폐막의 또 다른 하
나로 사용이 가능하리라 사료된다.
#초록#
In dentistry, bony defects can be formed by cyst, tumor, inflammation, trauma and
surgery in maxilla and mandible. If the overlying soft tissue invades and preoccupies the
jaw bony defects, regenerated bony tissue same as adjacent bone can not replace whole
space of the defects, thus preventing ostecgenesis form occurring, Guided bone
regeneration(GBR) is based of the prevention of overlying soft tissue from entering the
bony defect during the initial healing periods. E-polytetrafluoroethylene(e-PTFE) is one
of an effective and widely used barrier membrane for GBR, but it has the disadvantages
such as surgical removal and high price, To overcome such disadvantages of e-PTFE,
many investigators have proposed various absorbable barrier membranes.
Inexpensive oxidized cellulose(Surgicel ) membrane was shown to have
potential for use as an absorbable barrier membrane for regenerative procedure and it
would not require surgical removal.
The purpose of this study is to investigate the absorption periods of oxidized cellulose
at the implant site and usefulness as a mechanical barrier, preventing the ingrowth of
the overlying soft tissue into the bony defects.
Two bony defects were made in each tibia of a dog using drill and one defect
covered with oxidized cellulose and the other covered with oxidised cellulose and the
other covered with periosteum directly as control. The experimental animals were
sacrificed at lst-7th, 10th, 14th, 21th, 28th, day postoperatively. Inspection of the
specimens was done to evaluate gross changes. Specimens were examined
histopathologically by hematoxylin-eosin and Masson's trichrome staining under light
microscope.
The results were as follows:
1. There was no significant differences of inflammatory reaction between the
experimental and the control group.
2. The resorption of oxidized cellulose was almost completed within 14th day.
3. Histologically, bone formation in the experimental group was somewhat more than
that fo the control group at 10th, 14th, 2th and 28th day postoperatively. The bone
forming pattern of the experimental group was more regular than that of the control
group.
4. There was no evidence of soft tissue invasion into the bony defect in the
experimental group.
In conclusion, oxidized cellulose membrane night be used as an alternative absorbable
barrier membrane to prevent overlying soft tissue invasion into the bony defects.
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